JoF, Free Full-Text
Por um escritor misterioso
Last updated 21 setembro 2024
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by Paracoccidioides brasiliensis, a thermally dimorphic fungus, which is the most frequent endemic systemic mycosis in many Latin American countries, where ~10 million people are believed to be infected. In Brazil, it is ranked as the tenth most common cause of death among chronic infectious diseases. Hence, vaccines are in development to combat this insidious pathogen. It is likely that effective vaccines will need to elicit strong T cell-mediated immune responses composed of IFNγ secreting CD4+ helper and CD8+ cytolytic T lymphocytes. To induce such responses, it would be valuable to harness the dendritic cell (DC) system of antigen-presenting cells. To assess the potential of targeting P10, which is a peptide derived from gp43 secreted by the fungus, directly to DCs, we cloned the P10 sequence in fusion with a monoclonal antibody to the DEC205 receptor, an endocytic receptor that is abundant on DCs in lymphoid tissues. We verified that a single injection of the αDEC/P10 antibody caused DCs to produce a large amount of IFNγ. Administration of the chimeric antibody to mice resulted in a significant increase in the levels of IFN-γ and IL-4 in lung tissue relative to control animals. In therapeutic assays, mice pretreated with αDEC/P10 had significantly lower fungal burdens compared to control infected mice, and the architecture of the pulmonary tissues of αDEC/P10 chimera-treated mice was largely normal. Altogether, the results obtained so far indicate that targeting P10 through a αDEC/P10 chimeric antibody in the presence of polyriboinosinic: polyribocytidylic acid is a promising strategy in vaccination and therapeutic protocols to combat PCM.
Full article: Original Abstracts from the 18th Annual Meeting of ISMPP
Cureus, The Efficacy of Telepsychiatry in Addiction Patients: A Systematic Review
PubMed (AUSP) 2008
Parasitologia E Micologia Humana Download - Colaboratory
Flow chart for selection of research articles.
Big John / Slim Joe Font - Dafont Free
Healthcare, Free Full-Text
Journal of Internal Medicine - Wiley Online Library
IJMS, Free Full-Text
Free Samp 0.3C R3 - Colaboratory
Jot Regular : Download For Free, View Sample Text, Rating And More On
What Is Indexed Universal Life Insurance (IUL)?
Open Access Journals - HTC Library
PRISMA (Preferred Reporting Items for Systematic Review and
Flowchart for selection of research articles
Recomendado para você
-
Revista Robótica 112 by Revista Robotica - Issuu21 setembro 2024
-
AeC - Relacionamento com Responsabilidade - O que você tem feito com o tempo que gastava para se deslocar para o trabalho? Com muitas das rotinas agora adaptadas para o home office21 setembro 2024
-
Procedimento Concursal Atividades de Enriquecimento Curricular 2023/2024 - Município de Belmonte21 setembro 2024
-
Frontiers Porcine circovirus type 3: immunohistochemical detection in lesions of naturally affected piglets21 setembro 2024
-
JPM, Free Full-Text21 setembro 2024
-
AEC Daily - Login to Your Account21 setembro 2024
-
2020 Global Go To Think Tank Index Report by FOSDEH Foro Social de la Deuda Externa y Desarrollo de Honduras - Issuu21 setembro 2024
-
Full article: The Consumption of Fresh Organic Food: Premium Pricing and the Predictors of Willingness to Pay21 setembro 2024
-
Framework proposal for BIM implementation in Brazilian construction and development companies21 setembro 2024
-
Contratação de Técnicos no âmbito do Programa de Atividades de Enriquecimento Curricular (AEC) - 2023/202421 setembro 2024
você pode gostar
-
You can't tell me spongebob doesn't look adorable in these photos21 setembro 2024
-
Guys, new screenshot and information from steam, the caterpillar is named PJ Pug-a-pillar and we will meet Bunzo Bunny and Bron. : r/PoppyPlaytime21 setembro 2024
-
50pcs 1: 6 Cozinha Condimento Série Mistura aleatória# Novo Mini Snack Bag Simulação Loja de Conveniência Food Diy Doll House Ornamentos Miniatura Cena Brinquedo A A21 setembro 2024
-
3 Ways to Shut a Garage Door when the Sun Is Shining on the21 setembro 2024
-
Democratic Russia Flag : r/vexillology21 setembro 2024
-
Reglamento Selectivo para Juegos Panamericanos Santiago 202321 setembro 2024
-
hello kitty shirt black and white ids Roblox vibe place boys|TikTok Search21 setembro 2024
-
Park Trails: Sunrise & Sunset — Circle Canoe Games21 setembro 2024
-
Pokémon Link: Battle - Análise21 setembro 2024
-
DOORS: Original Rush Jumpscare VS FNF Mod (Comparison)21 setembro 2024