Temozolomide (NSC 362856), DNA Alkylator

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.

Temozolomide (NSC 362856), DNA Alkylator

Biomedicines, Free Full-Text

Imidazolecarboxamide - an overview

Temozolomide resistance in glioblastoma multiforme. - Abstract - Europe PMC

DNA Damage/DNA Repair - BioCrick

DNA/RNA合成阻害 DNA/RNA Synthesis Inhibition

Bioequivalence study of 20-mg and 100-mg temozolomide capsules (TOZ309 and Temodal®) in glioma patients in China

DNA Damage/DNA Repair - BioCrick

Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy - ScienceDirect