Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Last updated 10 novembro 2024
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
Co-Translational Folding: A Novel Modulator of Local Protein
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic
Pten heterozygosity restores neuronal morphology in fragile X
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis
IJMS, Free Full-Text
Frontiers Homeostatic Roles of the Proteostasis Network in Dendrites
Correction of Fragile X Syndrome in Mice - ScienceDirect
Dissociation of functional and structural plasticity of dendritic spines
Altered mRNA transport, docking, and protein translation in
Frontiers Fragile X Mental Retardation Protein Regulates
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic
Which Comes First in Fragile X Syndrome, Dendritic Spine
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